EvidenceMedicine.net

Evidence-based Medicine

Even a single additional stroke risk factor in patients with atrial fibrillation may confer a risk of stroke. However, there is no consensus on how best to treat these patients. The objective of a ...


Abdominal aortic aneurysm ( AAA ) repair aims to prevent premature death from AAA rupture. Elective repair is currently recommended when abdominal aortic aneurysm diameter reaches 5.5 cm ( men ) and 5 ...


Current guidelines recommend against revascularization of the noninfarct artery during the index percutaneous coronary intervention ( PCI ) in hemodynamically stable patients with ST-segment elevation ...


Acute kidney injury ( AKI ) is common in patients undergoing cardiac surgery among whom it is associated with poor outcomes, prolonged hospital stays and increased mortality. Statin drugs can produc ...


Many patients have symptoms suggestive of coronary artery disease ( CAD ) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide ca ...


In a multicentre study, 1320 patients presenting to the Emergency department with suspected acute myocardial infarction were enrolled. The high-sensitivity cardiac troponin T 1-hour algorithm, inc ...


Routine screening and supplementation for iron deficiency anemia ( IDA ) in asymptomatic, nonanemic pregnant women could improve maternal and infant health outcomes. The purpose of a study was the ...


Two different devices, 1 self-expanding and 1 balloon-expandable, have been developed for patients who underwent transcatheter aortic valve implantation with contrasting data about efficacy and safety ...


The objective of the study was to assess adverse outcomes in relation to the simplified Pulmonary Embolism Severity Index ( PESI ) score in patients treated with Rivaroxaban ( Xarelto ) or standard th ...


Statin therapy for sepsis has been suggested by observational studies. However, randomized controlled trials have not demonstrated this benefit. Researchers have conducted a systematic review and ...


There has been a decline in hospital length of stay after primary percutaneous coronary intervention ( PPCI ) for ST-segment elevation myocardial infarction ( STEMI ). The objective of this study w ...


A meta-analysis of randomised controlled trials has assessed the benefits and risks of short term ( less than 12 months ) or extended ( more than 12 months ) dual antiplatelet therapy ( DAPT ) versus ...


The optimal use of various therapeutic combinations for moderate/severe chronic obstructive pulmonary disease ( COPD ) is unclear. The GLISTEN trial compared the efficacy of two long-acting anti-mus ...


NIHSS ( National Institutes of Health Stroke Scale ) item profiles that were recently proposed may prove useful both clinically and for research studies. Researchers aimed to validate the NIHSS item ...


The optimal antiaggregant therapy after coronary stenting in patients receiving oral anticoagulants ( OACs ) is currently debated. Search for studies reporting outcomes of patients who underwent PCI ...


Early, goal-directed therapy ( EGDT ) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertain ...


Despite the prevalence and the functional, psychological, and economic impact of chronic pain, few intervention studies of treatment of chronic pain in veterans have been performed. A study has det ...


Immune activation has been reported in the mucosa of irritable bowel syndrome ( IBS ) patients with diarrhoea ( IBS-D ), and some small studies have suggested that Mesalazine ( 5-Aminosalicylic acid; ...


The addition of Bevacizumab to Fluorouracil-based chemotherapy is a standard of care for previously untreated metastatic colorectal cancer. Continuation of Bevacizumab beyond progression is an accepte ...


Conflicting data exist regarding the effects of statin therapy on the prevalence of inflammatory bowel diseases. A retrospective study has examined the association of statin therapy with diagnoses ...


PARTNER ( The Placement of Aortic Transcatheter Valves ) trial showed that mortality at 1 year, 2 years, and 3 years is much the same with transcatheter aortic valve replacement ( TAVR ) or surgical a ...


Lacunar stroke accounts for approximately 25% of ischemic stroke, but optimal antiplatelet regimen to prevent stroke recurrence remains unclear. A study has assessed the efficacy of antiplatelet a ...


Randomized controlled trials comparing short- ( less than or equal to 6 months ) with long-term ( greater than or equal to 1 year ) dual antiplatelet therapy ( DAPT ) after drug-eluting stent(s) ( DES ...


Idiopathic pulmonary fibrosis ( IPF ) is a life-limiting lung disease that generally affects people over 60 years old. The main symptoms are shortness of breath and cough, and as the disease progresse ...


Intra-aortic balloon pump counterpulsation ( IABP ) is currently the most commonly used mechanical assist device for patients with cardiogenic shock due to acute myocardial infarction. Although there ...


Controversy persists over statins and risk of intracerebral hemorrhage. Researchers have determined associations of premorbid lipid-lowering therapy and outcomes among participants of the Intensive Bl ...


Despite recent studies, the optimum duration of dual antiplatelet therapy ( DAPT ) after coronary drug-eluting stent placement remains uncertain. A meta-analysis with several analytical approaches t ...


Alirocumab ( Praluent ), a monoclonal antibody that inhibits proprotein convertase subtilisin – kexin type 9 ( PCSK9 ), has been shown to reduce low-density lipoprotein ( LDL ) cholesterol levels in p ...


Most ischaemic strokes are caused by a blood clot blocking an artery in the brain. Clot prevention with anticoagulants might improve outcomes if bleeding risks are low. This is an update of a Cochra ...


The aim of a study was to identify whether particular subgroups of patients had an unacceptably high risk of symptomatic intracranial hemorrhage or low chance of benefit when treated with Alteplase ( ...


Intracranial stenosis is one of the most common etiologies of stroke. According to Authors, no randomized clinical trials have compared balloon-expandable stent treatment with medical therapy in sympt ...


The objective of a study was to investigate the predictive performance of lactate, CURB-65, and a combination of lactate and CURB-65 ( LAC-CURB-65 ) for mortality, hospitalisation and intensive care u ...


Depression is common in diabetes and linked to adverse health outcomes. A study has evaluated the efficacy of a guided web-based intervention in reducing depression in adults with type 1 and type 2 di ...


Ovarian failure is a common toxic effect of chemotherapy. Studies of the use of gonadotropin-releasing hormone ( GnRH ) agonists to protect ovarian function have shown mixed results and lack data on p ...


Asthma exacerbations are commonly precipitated by viral upper respiratory infections ( URIs ). Vitamin D insufficiency associates with susceptibility to URI in patients with asthma. Trials of Vitami ...


Evidence from systematic reviews of observational studies suggests that hormone therapy may have beneficial effects in reducing the incidence of cardiovascular disease events in post-menopausal women, ...


Accurate risk assessment of atherosclerotic cardiovascular disease ( ASCVD ) is essential to effectively balance the risks and benefits of therapy for primary prevention. Researchers have compared ...


The objective of a study was to externally validate the SOAR stroke score ( Stroke subtype, Oxfordshire Community Stroke Project Classification, Age and prestroke modified Rankin score ) in predicting ...


Conflicting blood pressure-lowering effects of catheter-based renal artery denervation have been reported in patients with resistant hypertension. Researchers have compared the ambulatory blood pres ...


Systematic review with meta-analysis of randomised trials has analyzed the association between supervised physical activity and cancer-related fatigue in people diagnosed with any type of cancer, with ...


Digital breast tomosynthesis ( DBT ) is a three-dimensional mammography technique with the potential to improve accuracy by improving differentiation between malignant and non-malignant lesions. Th ...


Angioedema induced by treatment with angiotensin-converting-enzyme ( ACE ) inhibitors accounts for one third of angioedema cases in the emergency room; it is usually manifested in the upper airway and ...


The role of Tiotropium for the treatment of asthma has not yet been clearly defined. The aim of a systematic review was to assess the efficacy and safety of Tiotropium in patients with asthma. Rand ...


The aim of a study was to evaluate the effect of Atorvastatin on lipid lowering, cardiovascular events, and adverse events in women compared with men in 6 clinical trials. In the Incremental Decre ...


Silent infarction in the brain can be detected in around 34% of patients after carotid endarterectomy ( CEA ) and 54% after carotid angioplasty and stenting ( CAS ). A study has compared the risk of ...


The objective of a single-blind randomized controlled trial was to evaluate the efficacy of manual lymphatic drainage ( MLD ) in improving health-related quality of life ( HRQOL ), symptomatology, and ...


Among patients without cardiovascular disease ( CVD ) and low 10-year CVD risk, the risks of gastrointestinal bleeding and hemorrhagic strokes associated with Aspirin ( Acetylsalicylic acid ) use outw ...


Noninvasive ventilation is increasingly applied to prevent or treat acute respiratory failure, but its benefit on survival is still controversial for many indications. Researchers performed a meta-ana ...


Apixaban ( Eliquis ) is a novel oral anticoagulant which is approved for the management of atrial fibrillation and venous thromboembolism prophylaxis. There have been concerns regarding bleeding risks ...


The objectives of a systematic review and meta-analysis were to assess 1) the effectiveness of male-predominant plasma transfusion strategy for preventing transfusion-related acute lung injury and rel ...



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